Chemical Cognitive Enhancers

Pharmaceutical amphetamines (such as Adderall and Ritalin) These drugs have been used withouit a prescription, for their tirednessreducing and concentration-enhancing effects, by about 5% of students in U.S. colleges, according to a recent study, with some colleges reporting rates as high as 25%. Modafinil Modafinil is a nonamphetamine stimulant, marketed to help people with narcolepsy stay awake. It has been reported as popular with otherwise healthy individuals who are using it to mai...

 Nogo receptor 1 Key to a Plastic Mind

Formation of lasting memories is believed to rely on structural alterations at the synaptic level. We had found that increased neuronal activity down-regulates Nogo receptor-1 (NgR1) in brain regions linked to memory formation and storage, and postulated this to be required for formation of lasting memories. We now show that mice with inducible overexpression of NgR1 in forebrain neurons have normal long-term potentiation and normal 24-h memory, but severely impaired month-long memory in both...